Nanoemulsions: Innovative solutions for topical applications

Case studies (Franz cell experiments) prove the advantage

• Hydrocortisone (W/O/W nanoemulsion): Up to 3–4 times higher amounts of active ingredient in the subcutis and 2–3 times more active ingredient in the acceptor fluid compared to benchmark formulations.
• Ibuprofen (O/W nanoemulsion): Maximum active ingredient absorption into the skin and up to 4 times more active ingredient in the acceptor fluid compared to comparable products.

These results show that IMWITOR® 375-based nanoemulsions enable either significantly better bioavailability with the same amount of active ingredient or a reduction in the active ingredient dosage with the same bioavailability—with advantages in terms of cost, formulation economy, and tolerability.

Key features of IMWITOR® 375 nanoemulsions

• High active ingredient loading of up to 12%
• Improved solubility compared to non-encapsulated active ingredient delivery, e.g., tocopherol @ 100 mg/ml
• Particle size: 120–250 nm and smaller
• PDI < 0.2
• Sustainable “green chemistry” based on plant-based raw materials (such as sunflower, sugar beet, sugar cane, and rapeseed)
• Use in semi-solid and liquid dosage forms
• Patentable

Conclusion:

IMWITOR® 375-based nanoemulsions offer a modern, sustainable, and technologically interesting alternative to classic encapsulation and solubilization technologies. This opens up new opportunities for product range expansions and product innovations.

We will be happy to provide you with further details and studies on various active ingredients upon request. If you are interested, please contact:

• Nanoemulsionen als Formulierungsansatz für Topika - IOIOLEO 
• Wen-Kai Hsiao et.al., Opportunities of topical drug products in a changing dermatological landscape, European Journal of Pharmaceutical Sciences, Volume 203, 2024, 106913, https://doi.org/10.1016/j.ejps.2024.106913